Cancer cells have a different metabolism than normal cells, which allows them to survive longer and grow faster. Resistance to apoptosis is a key feature of cancer cells, and given the importance of mitochondria in apoptosis, it is crucial to study the behavior of mitochondria in tumors.

Indeed, the relationship between cancer development and mitochondrial dysfunction is manifested in various ways:

Warburg effect

Mitochondrial gene mutations

Mitochondrial biogenesis

Mitochondria structural and functional abnormalities

Cation Channels

In addition, nuclear gene mutations in conjunction with the following transcription factors and signaling pathways affecting mitochondrial function are also important in the development and metastasis of cancer.